The California Highway Patrol says a section north of 16th Street was reduced to one lane following the crash.
Officials have not released details about how the crash happened or if the driver sustained any injuries.
The crash damaged about 100 feet of the guardrail.
Caltrans is working to clear the road and get traffic flowing.
CHP is reminding the public to slow down, stay focused on driving, and move over when it is safe to do so.