The sheriff's office says 16-year-old Landon Wilson and 15-year-old Alizah Sandlin were last seen together at Sandlin's home around 1 a.m. Thursday morning.
Wilson has brown hair and hazel eyes.
He was last seen wearing black shorts, a maroon sweatshirt and a black hat.
Sandlin has brown hair and blue eyes.
She was last seen wearing a black hoodie, jeans and pink shoes.
Anyone with any information on their whereabouts should call the Mariposa County Sheriff's Office.