The shooting happened just after 12:30 a.m. Saturday on Clay Avenue near Rowell.
Officers say they responded to calls for multiple shots fired and a shot-spotter call.
When they arrived, police found a man in his 40s with a gunshot wound to his leg.
The man was taken to a nearby hospital for treatment with non-life-threatening injuries.
Officials say multiple cars and buildings were hit by gunfire and believe the suspect was driving a white sedan.
If you have information, you are asked to call the Fresno Police Department.