The crash happened just before 1 p.m. Thursday on Avenue 424 and Road 120, just north of Orosi.
The California Highway Patrol says the teen ran a stop sign and crashed into a PG&E crane truck.
The teenage driver died at the scene and was not wearing a seatbelt.
The driver of the PG&E truck sustained serious injuries and was taken to the hospital.
Alcohol or drugs are not suspected factors in the crash.