The man has been identified as 48-year-old James Harvey.
It happened around 6 pm Sunday near Bullard and First.
Fresno police said the driver of the car remained at the scene.
Officers do not believe drugs or alcohol are factors in the crash.
"We do believe that the pedestrian is at fault from what the preliminary investigation is showing us," says Fresno Police Lt. Henry Garcia.
Investigators believe Harvey was a member of the unhoused community.