It happened just after 10 pm Sunday on southbound Highway 41, just south of North Avenue.
Officers say a Chevy Camaro hit the back of a Dodge Ram pickup, spun out of control and struck a guardrail.
The Camaro soon caught fire. The driver of the Camaro ran from the scene.
A woman in the pickup complained of pain in her chest and was taken to a nearby hospital.
The man inside the truck was okay.
Officers do not have a description of the Camaro driver who remains on the loose.
It is not known if drugs or alcohol played a role in the crash.