Police were called out to Clovis Avenue and Inyo Street after 5:30 pm. Saturday night.
Officers say a woman in a wheelchair was hit while crossing Clovis Avenue.
She was taken to Community Regional Medical Center, where she died.
The road was closed for several hours during the investigation but has reopened.
Police are still looking for the driver.
If you have any information on this incident, you're asked to call the Fresno Police Department.