It happened just before 7:30 Wednesday morning on Highway 168, west of Little Sandy Road.
The California Highway Patrol says 43-year-old Richard Lewis of Auberry was driving a motorcycle when he rear-ended a Toyota.
Lewis was thrown from his motorcycle and then hit by a trailer. He died at the scene.
Investigators say Lewis was wearing a helmet at the time of the crash.
The drivers of the two other vehicles were not injured.