New York took third place, with San Francisco-Oakland, Washington D.C. and Philadelphia rounding out the top five Rattiest Cities.
The metro regions were ranked by the number of new rodent treatments performed from September 2018-2019.
The National Pest Management Association said 24 percent of homeowners report mice infestations specifically in winter, when the rodents seek shelter in warm areas.
RELATED: Rat tears into the sliced cheese at Food 4 Less supermarket
Orkin offers some tips to keep your property rat-free, including inspecting the inside and outside of your home for rodent droppings and sealing cracks, holes and other entry points.
They also recommend cleaning up any crumbs and spills immediately.