Starting Monday, both directions of McKinley Avenue between Highway 99 and West Avenue will be closed due to construction.
The 99 off-ramp to McKinley will also be closed.
The closure is due to the high-speed rail grade separation and the realignment of the McKinley and Golden State Boulevard intersection.
Officials say the closure is expected to last a year.
Drivers are asked to use Clinton and Olive Avenues or find an alternate route.