The crash happened Monday shortly before 1:00 am on Floral Avenue and A Street.
Investigators say Lizbeth Romero of Parlier crashed her Honda Accord into a Chevy Tahoe and then drove off.
Officers found her vehicle near Floral and E Street and say they saw a woman running from the car.
While searching the vehicle, police found a male passenger suffering from major injuries unconscious in the back seat. He was taken to a local hospital, where he later died. His name has not been released.
A short time later, Fresno County sheriff's deputies found Romero' and another woman hiding behind the gate of a nearby home.
Police say they both had non-life-threatening injuries and were also transported to a hospital for treatment.
Officials say Romero was on probation and had been arrested for DUI multiple times.
She is facing several charges, including vehicular manslaughter while intoxicated, hit-and-run, DUI and driving with a suspended driver's license.