It happened at about 2:30 Sunday morning on Highway 41 and Jewel Vista Drive, just south of Chukchansi Casino.
The California Highway Patrol says a Hyundai Elantra went off the road and crashed into several rocks.
A Toyota Tundra driving behind clipped the Hyundai, along with two other vehicles.
Several people suffered minor injuries, but a passenger in the Hyundai suffered major injuries.
The driver of the Hyundai was taken into custody for DUI.
The road was reopened after four this morning.