Fresno Police say around 6 PM a driver and a motorcyclist collided.
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Investigators say the motorcycle rider was taken to the hospital with serious injuries.
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The driver of the vehicle stayed on the scene and is cooperating with the investigation. Alcohol is not suspected as a factor.
During the investigation, traffic was able to access Highway 41 northbound from Shaw.
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But the southbound Highway 41 on-ramp was temporarily blocked and traffic was being turned around at Effie Street.