The first shooting happened just before 1 a.m. near White and Backer Avenues in East-Central Fresno. Police say officers found an injured man later identified as 22-year-old Manuel Lopez at the scene.
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Lopez was rushed to Community Regional Medical Center where he died.
Less than an hour later, officers were alerted to gunfire near Willow and Inyo Avenues by the department's ShotSpotter system. Police discovered 40-year-old Paul Cerrato had been shot multiple times and rushed him to the hospital where he also died.
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At this point, police are not sure if the two incidents are related. Detectives are interviewing witnesses in the area and are asking the public for help.
Anyone with information is asked to contact the Fresno Police Department.