Officers were called to a store near Clovis and Shaw just before 4 pm Wednesday for a shoplifting.
The caller told dispatchers two men ran out of the store with hundreds of dollars of baby formula and left in a car.
Officers spotted that car on Shaw and tried to pull them over, but they sped off.
A pursuit began but was called off a short time later.
Minutes after that, a Clovis Police Detective spotted a crash at Clovis and Shields, involving the suspect's car.
With the help of Fresno police officers and Fresno County Sheriff's deputies, 32-year-old Justin Deger and 28-year-old Dylan Ray were arrested nearby and later booked into the Fresno County Jail.
The stolen baby formula was returned to the store.