Among its 6,000 sailors are hundreds from the Lemoore Naval Air Station.
This deployment marks the second time the Carl Vinson Strike Group will operate throughout the Indo-Pacific region.
Family and friends watched as the carrier took off and it was a bittersweet moment for those on board and on land.
The strike group is traveling with a missile cruiser and guided-missile destroyers. It's last deployment to the Indo-Pacific region wrapped up last June.
According to officials from NAS Lemoore, this deployment is roughly scheduled to be three months long.