It happened at about 4:30 Monday morning at a home on Iowa and Barton.
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Police say the victims woke up when they heard the gunshots.
They were taken to Community Regional Medical Center and are expected to recover.
Police say a total of 12 people were home at the time of the shooting, including nine children.
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They range in age from 10 months to 17 years old.
The two adult victims were the only ones hurt.
There's no word yet on any suspects.