California Highway Patrol officers were called to northbound Highway 99 near Highway 180 just before 3 Saturday morning.
Investigators say a Honda rear-ended a truck and then became stuck in the middle lane.
A tow-truck driver pulled over and was helping to get the Honda out of the road when a motorcyclist approached, lost control and crashed into the Honda and tow truck.
The 28-year-old Honda driver sustained minor injuries and was taken to Community Regional Medical Center.
He is suspected of driving under the influence.
The motorcycle driver was also injured and hospitalized.