The Fresno Fire Department wrote on social media that the fire was burning in a two-story building off Blackstone Avenue between Dakota and Garland Avenues.
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Fire officials said they had requested more firefighters to the scene, and that crews were working in "rescue mode."
Further information on what sparked the fire wasn't immediately available.
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Officials are asking drivers and residents to avoid the area while firefighters work to douse the flames.
This is a developing breaking news story. Stay with us for updates.