Negotiations had been going on for the past week, but nothing could be agreed upon, leading to the strike.
Fixed route bus services, Dial-A-Ride, Sequoia Shuttle and V-Line are all suspended until Transdev can find drivers.
Officials say that Dial-A-Ride would be a priority if drivers are found since they help the elderly and those with disabilities.
The strike will affect bus riders in Visalia, Farmersville, Exeter and Goshen.