California Highway Patrol investigators say the crash happened along Highway 137 near Road 152, and it knocked the victims' car on its side. Witnesses lifted it back onto the wheels, put the fire out, and pulled out all four people - including two children.
Paramedics took a two-week-old baby, the mother and a passenger to the hospital with major injuries and a toddler also suffered minor injuries.
Nicole Jimenez, 27, was arrested at the scene on DUI charges.