The California Highway Patrol says it happened near Highway 216 and King Drive around 3:30 pm.
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Officers say a 21-year-old woman was going south on Highway 216 when a 69-year-old woman in front of her was trying to turn into a private driveway.
As the 69-year-old woman was turning, traffic slowed down behind her and the 21-year-old did not notice.
Officers say 21-year-old swerved to avoid hitting the car but went off the roadway and hit the back of the 69-year-old's car.
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That crash pushed the 69-year-old's car into the back of a tractor trailer. She was pinned between the trailer and the other car.
She was removed from the car and taken to Kaweah Health Medical Center, where she died.
The 21-year-old is cooperating with the investigation. Drugs or alcohol do not appear to be factors.