The California Highway Patrol says it happened near Highway 41 and Elkhorn Avenue around 5:30 pm.
Officers say the semi-truck was making a turn to go on Highway 41 northbound when a Hyundai ran a red light.
The man driving the Hyundai was pinned under the semi-truck and later was taken to the hospital. Once released, he will be booked into jail for DUI.
The driver of the semi-truck was not injured and is cooperating with officers.