Officials say the woman was driving south on Avenal Cutoff Road near 25th Avenue when she tried to make a three-point turn.
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An oncoming big rig traveling north on Avenal Cuttoff Road hit the woman's Lexus as she made the turn.
The car then hit another semi-truck that stopped in the southbound lane while the Lexus turned.
The woman was airlifted to Community Regional Medical Center in Fresno, where she later died.
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Both big rig drivers were not hurt.