According to the Federal Aviation Administration, the ill-fated Cessna took off from Fullerton Municipal Airport before the incident.
Shortly after 2 p.m., a spokesperson for the Orange County Fire authority said there were at least two active structure fires at the scene on Canyon Drive near Crestknoll Drive.
The Fire Authority later confirmed the death toll and number of injured. The deceased were not immediately identified. The conditions of the survivors, who suffered burn injuries, were unknown.
A witness' video shows a two-story home engulfed by a massive inferno as horrified neighbors look on and two explosions are heard.
A witness' video showed at least one home engulfed in an inferno in the residential neighborhood as horrified neighbors looked on. What appeared to be a small piece of possible wreckage from a plane was burning in the street.
Anaheim firefighters were assisting in the response, along with deputies from the Orange County Sheriff's Department.
DEVELOPING: More details will be added to this report as they become available.