Firefighters were called to a home just before 2 p.m. on Highway 245 near Dunlap Road just south of Pinehurst.
The fire destroyed one home, destroyed a few vehicles and possibly displaced two people.
Investigators are now trying to determined what started the fire and where it started.
CalTrans says Highway 245 is closed due to the fire. There was no estimated time of reopening provided.
Stay with ABC30 for the latest details on this developing story.