It happened just before 4:30 a.m. at Cornelia and Holland Avenues after a party ended up the street.
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Investigators say one man was shot in the foot, and the other was shot in the leg. Both were taken to a nearby hospital.
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Officers say a girlfriend of one of the victims was detained briefly for questioning. The men have not been cooperative with the police.
Officials have not released a suspect description at this time.