The crash happened around 3:30 pm in the area of Highway 165 and Westside Boulevard.
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Officials with the California Highway Patrol say a driver lost control, veered into the opposite lane, and crashed head-on into a vehicle.
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Investigators say the driver of the second vehicle was killed in the crash.
The other driver was taken to a local hospital in an unknown condition.
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Officers say it was raining at the time of the crash, but the cause is still under investigation.
Drugs or alcohol are not believed to have been involved.