California Highway Patrol officers say a Toyota Camry was struck multiple times by gunfire just after 10 pm on Highway 180 east of the Highway 99 connector.
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The female driver was found dead inside the car. A passenger in her car was also shot and taken to Community Regional Medical Center.
"All indications are right now that this may be a gang-related shooting just based on what we're finding right now with the preliminary investigation at the scene," said CHP Officer Mike Salas.
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Several shell casings were found across Highway 180.
Authorities do not have any suspect information or a description of the suspect's car at this time.
Westbound Highway 180 is closed between Fulton Street and the Highway 99 ramp. It's unclear when the freeway will reopen.