Caltrans says the crash is on northbound Highway 41 just north of Ashlan Avenue.
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Caltrans did not say how many cars were involved in the crash.
There is no estimated time for the accident to be cleared.
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You are asked to avoid the area if possible.
To track traffic conditions throughout Central Californai, use the ABC30 Live Traffic Tracker.
Stay with ABC30 for the latest details on this developing story.