The crash happened in the area of Highway 99 & Avenue 18 1/2 on Saturday morning.
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This is in the same area as one of two deadly crashes in Madera County last weekend.
RELATED: 1 killed in Madera County's second deadly head-on crash this weekend
An ABC30 crew at the scene saw a pickup truck that had gone off the road and landed in a field next to the highway.
It's unknown what caused the driver to lose control of the truck but the crash caused him to be ejected from the vehicle and land in a nearby ditch.
The front part of the truck appeared to be badly damaged.
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Emergency crews declared the driver dead at the scene.
Sheriff's deputies, California Highway Patrol officers, and a medical examiner were at the scene.
Traffic was not disrupted.