Deputies were called out to Scaggs and Juanche Avenues just after 2:30 am.
When they arrived, they found a 19-year-old man and an 18-year-old woman suffering from multiple gunshot wounds inside a crashed vehicle.
Paramedics rushed the man to a Fresno hospital by air flight, and the woman was taken by ambulance.
The Fresno County Sheriff's Office said both victims are expected to survive.
Investigators found shells casings three blocks away from the crash site, and the victims' car had some bullet holes.
Deputies are working to determine what led up to the shooting.