The shooting happened around 7:30 pm in the area of J and 10th streets, according to the Fresno County Sheriff's Office.
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When deputies arrived, they found 18-year-old Ruben Velazquez of Orange Cove and a 17-year-old inside a car.
Both had been shot and were taken to the hospital.
Velazquez later died from his injuries.
The 17-year-old remains hospitalized and is listed in critical condition, authorities say.
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Detectives are working to identify the suspect and vehicle involved.
Deputies say this is possibly a gang-related shooting.
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Stay with Action News for updates on this developing story.