One of them, a minor, has burn injuries, Fresno Fire says.
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The blast happened in northeast Fresno at the intersection of First Street and Shaw Avenue at about 2:30 pm on Friday afternoon. The food truck and the pickup truck hauling it went up in flames right after.
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Pictures of the aftermath show the food truck badly charred, its sides hanging off and blackened.
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Debris appeared to be scattered hundreds of feet away.
More than 30 firefighters rushed to fight the flames.