24-year-old Krishan Kumar and 31-year-old Vishal Vishal were arrested and each was charged with murder.
33-year-old Kuvar Kumar was shot and killed at State Street and Acacia Avenue on July 21.
Detectives say he was gunned down while arriving home in the evening.
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They believe the victim knew the suspects and that there was a business conflict between them that led up to the shooting.
It was discovered that neither of the suspects lives in Fresno.
"Several potential witnesses were interviewed around the state of California, we authored numerous search warrants in this case, and as I said the case did take us not just across the state of California but actually across the nation as well," Fresno Police Chief Mindy Casto said.
Search warrants were conducted at the suspect's homes in Bakersfield and Victorville, where they were arrested and guns were recovered.
Both have been booked into the Fresno County jail and have bail set at more than $1 million.