The shooting happened around 6 pm near Clay Avenue and Fisher Street, just north of Highway 180.
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Fresno police say a man was found with a gunshot wound to his upper body.
He was rushed to a local hospital in critical condition.
It is unclear what happened leading up to the shooting.
No arrests have been made at this time.
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Officers have taped off the intersection as the investigation continues.
It is unknown when the roadway will reopen.
Stay with Action News for the latest updates on this developing story.