The shooting happened around 9:30 pm in the area of Roosevelt and Arroyo avenues.
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After knocking on the woman's front door, Fresno police say the man began to argue with her.
During the exchange, officials say the man shot into the home, breaking a window.
Investigators say the woman grabbed her own gun and shot back at the man, hitting him in the thigh.
After being shot, police say the man tried for a second time to shoot the woman but missed again.
The man left the house after the shooting and went to ask for help at the home of someone he knew.
The man was taken to a local hospital and is now in police custody.
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The woman was not injured in the shooting.
It's unclear what the argument was over, but police say the man and woman have a history of past incidents between them.
Officials say shots were fired into the woman's home a week ago, but the motive behind that shooting is unknown.
Police did recover the handgun used by the man in this incident.
Stay with Action News for updates on this developing story.