The pharmacy chain is opening around a dozen stores this year that are about half the size of its traditional layout and have only a pharmacy
Reductions will occur in "non-customer facing positions," primarily affecting its corporate staff.
Big chains have closed stores in major US cities recently, raising alarm about the future of retail in some of the country's most prominent downtowns.
An apparent shortage of pharmacists is forcing CVS and Walmart to reduce the hours of its pharmacies, as they close earlier in thousands of locations.
The change comes after high demand for children's pain and fever medications led some stores, including CVS and Rite Aid, to limit purchases.
Increased demand has led CVS and Walgreens to limit purchases of children's pain-relief medicine, the companies confirmed to CNN on Monday.
