The woman has been identified as 34-year-old Amanda Smith.
California Highway Patrol officers say it happened just before 5 pm near Highway 180 and DeWolf.
Officers say that a man was driving west on Highway 180 and east of DeWolf when the right rear tire tread separated from the tire.
The man was unable to control the car and went into the opposite lane. He collided head-on with an Infinity and Ford Focus in different lanes.
Officers say Smith was pronounced dead at the scene. The two other men were taken to Community Regional Medical Center with injuries.
CHP says alcohol and drugs do not appear to be factors at this time.
EDITOR'S NOTE: The video above is from a previous broadcast and will be updated.