It happened before 10:00 pm on westbound Highway 180 at Brawley Avenue.
California Highway Patrol officers say a Toyota pickup was westbound on the highway. The driver was about to go on a green light when a Chevy Sonic rear-ended them.
Two men in the pickup were hurt. The driver was transported to Community Regional Medical Center in downtown Fresno with complaints of chest pain and a nosebleed.
His passenger refused treatment.
CHP officers arrested the driver of the Chevy for driving under the influence.