It happened around 2 am.
The California Highway Patrol says Destiney Perez of Fresno was northbound on the highway when, for an unknown reason, she lost control of her truck.
The truck's front tire hit a concrete curb, and the vehicle hit a light pole before going up an embankment and overturning back down the hill.
The truck landed on its roof.
Perez was pronounced dead at the scene.
Officials believe alcohol may have been a factor in the crash.