The crash happened after 8 pm on De Wolf and Floral Avenues, east of Selma.
CHP officials said the 71-year-old man was driving west on Floral Avenue when he turned his Chevy Suburban directly in front of an oncoming Chevy Silverado.
The two vehicles collided head-on, killing the driver of the Suburban.
The Silverado caught fire, and witnesses at the scene helped pull two men trapped inside out of the vehicle. Both men were taken to a Fresno hospital with severe injuries.
Investigators said it's unclear if alcohol was a factor in the crash.