The Mississippi Health Department took to social media Friday to issue a warning about the phenomenon, which has been reported throughout the pandemic.
"Do not use ivermectin products made for animals," it said in a Facebook post.
The Mississippi Health Department also issued an alert Friday to health care providers in the state regarding the increase in poison control calls due to potential ivermectin toxicity.
"At least 70% of the recent calls have been related to ingestion of livestock or animal formulations of ivermectin purchased at livestock supply centers," stated the alert, which did not specify the number of total calls.
The warning comes as Mississippi is experiencing record COVID-19 cases and hospitalizations, and intensive care units are nearing capacity. Mississippi currently has the highest COVID-19 case rates in the country and the second-lowest vaccination rate, according to recent data from the U.S. Centers for Disease Control in Prevention.
Ivermectin can be deadly in large doses. Most callers to Mississippi's poison control center had mild symptoms, though one person was advised to seek further care "due to the amount of ivermectin reportedly ingested," according to the alert.
Earlier this week, state health officials said they knew of at least one person in Mississippi who was hospitalized due to ivermectin-related toxicity.
"I think some people are trying to use it as a [COVID-19] preventative, which I think is really kind of crazy, so please don't do that," Mississippi State Health Officer Dr. Thomas Dobbs said during a press briefing Wednesday.
You are not a horse. You are not a cow. Seriously, y'all. Stop it. https://t.co/TWb75xYEY4— U.S. FDA (@US_FDA) August 21, 2021
"You wouldn't get your chemotherapy at a feed store. I mean, you wouldn't treat your pneumonia with your animal's medication," he continued. "It can be dangerous to get the wrong doses of medication, especially for something that's meant for a horse or a cow. We understand the environment we live in, but it's really important, if people have medical needs, go through your physician or provider."
In animals, ivermectin is commonly used to treat or prevent parasites. Ivermectin tablets are approved by the Food and Drug Administration to treat several conditions caused by parasitic worms in people, and topical forms are approved to treat conditions like head lice and rosacea. But it is not approved to treat or prevent COVID-19.
Back in March, the FDA warned against using "unconventional treatments," such as ivermectin, that aren't approved or authorized by the agency to treat or prevent COVID-19, saying they can "cause serious harm."
The warning came following "multiple reports of patients who have required medical support and been hospitalized after self-medicating with ivermectin intended for horses," the FDA said in a consumer update.
The high doses in ivermectin products for animals "can be highly toxic in humans," the FDA warned. Versions of the drug approved for humans could also interact with other medications, and people could overdose and potentially die, the agency said.
ABC News' Brian Hartman contributed to this report.