The California Highway Patrol says the two vehicles collided before 6:30 am on Turner Island Road and Palazzo Road, northwest Dos Palos.
Officers say the tractor driver called for help.
The car driver was pronounced dead at the scene.
Further information regarding the crash wasn't immediately available.
Investigators are now working to determine what caused the two vehicles to collide.
The CHP has blocked off the intersection while officers continue their investigation. Drivers are advised to avoid the area.