It happened after 12:30 am on North and Temperance Avenue, just southeast of Fresno city limits.
Sheriff's deputies say a Toyota RAV 4 failed to stop at Temperance and went into the path of a Toyota Corolla.
The Corolla hit the passenger side of the RAV 4, causing the vehicle to roll into a dirt field.
The drivers of both cars suffered injuries. The 19-year-old passenger in the RAV was thrown from the vehicle and died at the scene.
Officials say the 19-year-old was from Clovis.
CHP officers say the passenger was not wearing his seat belt.
Alcohol or drugs do not appear to be factors in the crash.