Arcia pitched two innings of relief and hit his sixth home run in the Angels' 21-3 loss to the Oakland Athletics on Thursday.
In doing so, Arcia became the first player to catch, pitch and homer in the same game in the modern era (since 1900), according to Elias Sports Bureau.
Informed by the Angels of his feat, Arcia said, "I'm pretty happy, I guess."
Arcia, 29, was already in the record books after driving in 10 runs in his first two games after being called up from the minors on July 26.
Arcia also became the first Angels position player to pitch since 1993, when he threw one scoreless frame against the A's on Aug. 11, but hadn't done much since.
That changed Thursday when the Angels fell behind by double digits early. Manager Mike Scioscia felt no need to tax his bullpen, so he turned to Arcia.
Arcia needed only five pitches to retire the first two batters before allowing three consecutive hits, including back-to-back home runs by Nick Martini and Chad Pinder.
"Just BP fastballs," Arcia said when asked what his repertoire included. "Played catch with my catcher, that's it."
Mark Canha singled off Arcia with one out in the eighth, but Dustin Fowler hit into an inning-ending double play.
Arcia then homered off Chris Hatcher in the ninth.
"That's a nice little note for Frankie, for sure," Scioscia said.
Arcia has been splitting time at catcher with Jose Briceno ever since the Angels traded Martin Maldonado to the Houston Astros and Rene Rivera was claimed off waivers by the Atlanta Braves.
"I just play hard," Arcia said. "Wherever they put me, I'll play hard."
The Associated Press contributed to this report.
Arcia first to catch, pitch and homer in same game
Angels catcher Francisco Arcia becomes the first player in MLB history to catch, take the mound and hit a home run in Los Angeles' 21-3 defeat in Oakland.