It happened around 10:30 a.m. near Ashlan Avenue.
Authorities say two pick-up trucks collided when one attempted to pass the other on the westbound lane.
The driver of a white truck rolled over into the eastbound lane, officials say. He died at the scene. Officers say he was not wearing a seatbelt.
The driver in the second truck was not injured and was allowed to drive away from the crash. Officers say he will not face charges in the crash.
Caltrans officials have shut down all eastbound lanes on the highway and advise drivers to use an alternate route.
FRESNO: Eastbound State Route 168 is currently CLOSED at Ashlan due to a multi-vehicle collision. Advise alternate route, no ETO at this time. pic.twitter.com/SxuRYWKiFe— Caltrans District 6 (@CaltransDist6) July 25, 2019
This is a developing story and will be updated.