The California Highway Patrol says the violent wreck happened near Zediker and Belmont just before 6 pm when a Toyota Camry tried passing two vehicles.
That's when the Camry slammed head-on with a Toyota Corolla.
The 41-year-old man driving the Camry, later identified as Erin Olsen of Kingsburg, died at the scene.
The 42-year-old man driving the Corolla, later identified as Jose Ruiz Zelaya of Fresno, also died.
The California Highway Patrol says it appears alcohol played a factor in the crash, but they are still waiting for toxicology results.