The California Highway Patrol says the rider, a man in his late twenties or early thirties, was at Friant Road and Lost Lake Road at about 11 am when the crash happened.
According to witnesses, he was speeding on the shoulder of Friant Road when he flew over the concrete and hit the other side.
He died at the scene.
Authorities are still investigating the crash. They say the motorcyclist was wearing a helmet.
This is the second deadly motorcycle crash in the Fresno area in two days.
RELATED: Motorcyclist killed in crash with truck in northeast Fresno
On Saturday, a motorcyclist died after crashing his bike into the back of a truck in northeast Fresno.