Chappelle, 48, and the unidentified individual appeared to tussle on the stage floor during the Netflix Is A Joke Fest, before the individual ran away behind a screen on stage. Security personnel then surrounded and tackled the person in the rear corner of the stage.
Chappelle appeared to run toward the altercation, saying the individual was being "stomped." He asked repeatedly for security to remove the person from the stage. While the individual was being subdued by security, Chappelle joked to the audience that the person was "a trans man." The comedian has been criticized for his remarks about the transgender community, and there was backlash last year against his hourlong Netflix special "The Closer," during which he said that "gender is a fact."
A man is transported into an ambulance at the Hollywood Bowl, in Los Angeles, May 3, 2022. (Theodore Nwajei via Reuters)
Police sources told ABC News that the suspect had a gun-shaped knife in his possession when he was arrested.
Chappelle is "fully cooperating" with the police investigation, his representative said in a statement.
"The performances by Chappelle at the Hollywood Bowl were epic and record-breaking and he refuses to allow last night's incident to overshadow the magic of this historic moment," the statement read.
A Netflix spokesperson also released a statement expressing concern for "the safety of creators."
"We strongly defend the right of stand-up comedians to perform on stage without fear of violence," the statement read.
Video circulating online and verified by ABC News showed the chaotic scene outside the Hollywood Bowl after the show, as police and medics loaded a person into an ambulance who was restrained and appeared to be the suspect. The incident occurred toward the end of the sixth night of the 11-day Netflix Is A Joke Fest, which runs until May 8 and features more than 130 performers at various venues across Los Angeles.
Comedian Dave Chappelle attends the opening night party presented by Netflix Is A Joke Fest at W Hollywood in Hollywood, California, on April 28, 2022. (Phillip Faraone/Getty Images for Netflix)
Comedian Chris Rock, who performed earlier in the night, came on stage with Chappelle moments after the attack and joked: "Was that Will Smith?"
Last month at the 94th Academy Awards, actor Will Smith walked on stage and slapped Rock across the face after the comedian made a joke about Smith's wife, Jada Pinkett Smith, during his presentation for Best Documentary Feature. The Academy of Motion Picture Arts and Sciences' Board of Governors has since banned Smith from attending any academy event or program, including the Oscars, for 10 years.
ABC News' Alice Chambers and Alex Stone contributed to this report.